{"id":14120,"date":"2021-08-27T04:00:48","date_gmt":"2021-08-27T02:00:48","guid":{"rendered":"http:\/\/news-papers.eu\/?p=14120"},"modified":"2021-08-24T11:10:14","modified_gmt":"2021-08-24T09:10:14","slug":"infografik-von-crit-care-zur-antibiotikatherapie-bei-ventilator-assoziierter-pneumonie-vap","status":"publish","type":"post","link":"http:\/\/news-papers.eu\/?p=14120","title":{"rendered":"Infografik von Crit Care zur Antibiotikatherapie bei Ventilator Assoziierter Pneumonie (VAP)"},"content":{"rendered":"<div class=\"page\" title=\"Page 1\">\n<div class=\"section\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p style=\"text-align: justify\">Ceftolozan\/Tazobactam ist f\u00fcr die Behandlung von im Krankenhaus <strong>erworbener\/ventilatorassoziierter bakterieller Lungenentz\u00fcndung<\/strong> (HABP\/VABP) in der doppelten Dosis zugelassen, die f\u00fcr andere Infektionsherde zugelassen ist. Unter den Subtypen der nosokomialen Lungenentz\u00fcndung ist die beatmete HABP (vHABP) mit der geringsten \u00dcberlebensrate verbunden. In der randomisierten, kontrollierten ASPECT-NP-Studie hatten Teilnehmer mit vHABP, die mit Ceftolozan\/Tazobactam behandelt wurden, eine niedrigere 28-Tage-Gesamtmortalit\u00e4t (ACM) als diejenigen, die Meropenem erhielten. Wir haben eine Reihe von Post-hoc-Analysen durchgef\u00fchrt, um die klinische Bedeutung dieses Ergebnisses zu untersuchen.<\/p>\n<blockquote><p><strong>Timsit JF et al. Ceftolozane\/tazobactam versus meropenem<\/strong>\u00a0<strong>in patients with ventilated hospital-acquired bacterial pneumonia: subset analysis<\/strong>\u00a0<strong>of the ASPECT-NP randomized, controlled phase 3 trial. Crit Care (2021) 25:290 (<a href=\"https:\/\/ccforum.biomedcentral.com\/track\/pdf\/10.1186\/s13054-021-03694-3.pdf\" target=\"_blank\" rel=\"noopener\">PDF<\/a>)<\/strong><\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" data-attachment-id=\"14121\" data-permalink=\"http:\/\/news-papers.eu\/?attachment_id=14121\" data-orig-file=\"https:\/\/i0.wp.com\/news-papers.eu\/wp-content\/uploads\/2021\/08\/Bildschirmfoto-2021-08-22-um-12.01.03-e1629626481260.png?fit=700%2C384\" data-orig-size=\"700,384\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Bildschirmfoto 2021-08-22 um 12.01.03\" data-image-description=\"\" data-image-caption=\"\" data-large-file=\"https:\/\/i0.wp.com\/news-papers.eu\/wp-content\/uploads\/2021\/08\/Bildschirmfoto-2021-08-22-um-12.01.03-e1629626481260.png?fit=1024%2C561\" class=\"alignnone wp-image-14121\" src=\"https:\/\/i0.wp.com\/news-papers.eu\/wp-content\/uploads\/2021\/08\/Bildschirmfoto-2021-08-22-um-12.01.03.png?resize=757%2C414\" alt=\"\" width=\"757\" height=\"414\" \/><\/p>\n<p style=\"text-align: justify\"><strong>Schlussfolgerungen:<\/strong> Es gab keine grundlegenden Unterschiede zwischen den Behandlungsarmen, die den beobachteten \u00dcberlebensvorteil von Ceftolozan\/Tazobactam in der vHABP-Untergruppe verf\u00e4lscht h\u00e4tten. Nach Bereinigung um klinisch relevante Faktoren, die sich in dieser Studie signifikant auf die ACM auswirkten, war das Sterberisiko bei Teilnehmern mit vHABP mehr als doppelt so hoch, wenn sie mit Meropenem im Vergleich zu Ceftolozan\/Tazobactam behandelt wurden.<\/p>\n<p><strong>Infografik\/Abbildung<\/strong> von<a href=\"https:\/\/ccforum.biomedcentral.com\/track\/pdf\/10.1186\/s13054-021-03694-3.pdf\" target=\"_blank\" rel=\"noopener\"><strong> Crit Care<\/strong><\/a>. Lesen Sie hier den ganzen Artikel.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ceftolozan\/Tazobactam ist f\u00fcr die Behandlung von im Krankenhaus erworbener\/ventilatorassoziierter bakterieller Lungenentz\u00fcndung (HABP\/VABP) in der doppelten Dosis zugelassen, die f\u00fcr andere Infektionsherde zugelassen ist. Unter den Subtypen der nosokomialen Lungenentz\u00fcndung ist [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":14121,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"__cvm_playback_settings":[],"__cvm_video_id":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"categories":[5],"tags":[149,2143,2144],"class_list":["post-14120","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-infektionen","tag-antibiose","tag-crit-care","tag-vap"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/news-papers.eu\/wp-content\/uploads\/2021\/08\/Bildschirmfoto-2021-08-22-um-12.01.03-e1629626481260.png?fit=700%2C384","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p7fR2g-3FK","jetpack-related-posts":[{"id":15773,"url":"http:\/\/news-papers.eu\/?p=15773","url_meta":{"origin":14120,"position":0},"title":"Sichelzellan\u00e4mie &#8211; Eine \u00dcbersicht","author":"Michael Bernhard","date":"Juli 31, 2022","format":false,"excerpt":"Patricia Kavanagh und Kollegen haben eine interessante \u00dcbersicht in JAMA zur Sichzellkrise\/-an\u00e4mie\u00a0publiziert.\u00a0In den USA leiden etwa 100.000 Menschen an Sichelzellan\u00e4mie, die sich durch h\u00e4molytische An\u00e4mie, akute und chronische Schmerzen, ein akutes Thoraxsyndrom, ein erh\u00f6htes Auftreten von Schlaganfall, Nephropathie und Retinopathie sowie eine um 20 Jahre k\u00fcrzere Lebenserwartung als die Allgemeinbev\u00f6lkerung\u2026","rel":"","context":"In &quot;Notaufnahme&quot;","block_context":{"text":"Notaufnahme","link":"http:\/\/news-papers.eu\/?cat=2083"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4887,"url":"http:\/\/news-papers.eu\/?p=4887","url_meta":{"origin":14120,"position":1},"title":"Propofolinfusionssyndrom &#8211; Was sagt die B\u00c4K?","author":"Michael Bernhard","date":"Juli 26, 2017","format":false,"excerpt":"Die Arzneimittelkommission der Deutschen \u00c4rzteschaft hat in einer Bekanntmachung im Deutschen \u00c4rzteblatt einen Beitrag zum\u00a0Propofolinfusionssyndrom - Empfehlung f\u00fcr eine erh\u00f6hte Sicherheit\u00a0(PDF) publiziert. 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