{"id":1202,"date":"2016-04-30T04:32:15","date_gmt":"2016-04-30T03:32:15","guid":{"rendered":"http:\/\/news-papers.eu\/?p=1202"},"modified":"2016-04-23T07:27:31","modified_gmt":"2016-04-23T05:27:31","slug":"haetten-sie-es-gewusst","status":"publish","type":"post","link":"http:\/\/news-papers.eu\/?p=1202","title":{"rendered":"Ketamin – H\u00e4tten Sie es gewusst ?"},"content":{"rendered":"

\"Ketamin\"Ketamin<\/strong> wird seit Jahren beim Status asthmaticus und generell bei Bronchoobstruktion aufgrund seiner bronchodilatatorischen Wirkung eingesetzt. Dabei ist ein ganz interessanter Aspekt, dass das R-Enantiomer<\/strong> eine deutlich gr\u00f6ssere bronchodilatatorische Wirkung hat im Vergleich zum S-Enantiomer<\/strong>. Dies hat auch ganz praktische Konsequenzen, w\u00e4hrend das bekannte Ketamin, also das Razemat<\/strong> aus R- und S-Enantiomer, bronchodilatatorisch wirkt, ist dieser Effekt beim S-Ketamine (Esketamin) deutlich weniger ausgebildet.<\/p>\n

Sie glauben es nicht? In folgenden Literaturstellen k\u00f6nnen Sie es nachlesen:<\/p>\n

\n

Denmark KT, et al. Ketamine To Avoid Mechanical Ventilation In Severe Pediatric Asthma. J Emerg Med 2006; 30: 163-166<\/strong><\/em><\/p>\n

Craven R. Ketamine. Anaesthesia 2007; 62 (suppl 1): 48-53<\/strong><\/em><\/p>\n

Pabelick CM, et al.\u00a0Stereospecific effects of ketamine enantiomers on canine tracheal\u00a0smooth muscle. Br J Pharmacol 1997; 121: 1378-1382<\/strong><\/em><\/p>\n<\/blockquote>\n

Als potentielle Wirkmechanismen werden dabei f\u00fcr das Ketamin diskutiert:<\/p>\n

    \n
  • zentrale Effekte mit Katecholaminfreisetzung, die aufgrund des \u00df2-sympathomimetischen Effektes zu einer Bronchodilatation f\u00fchren.<\/li>\n
  • Inhibition von vagalen Pathway, die zu einer anticholinergen Wirkung an der glatten Bronchialmuskulatur f\u00fchren.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    Ketamin wird seit Jahren beim Status asthmaticus und generell bei Bronchoobstruktion aufgrund seiner bronchodilatatorischen Wirkung eingesetzt. Dabei ist ein ganz interessanter Aspekt, dass das R-Enantiomer eine deutlich gr\u00f6ssere bronchodilatatorische Wirkung […]<\/p>\n","protected":false},"author":2,"featured_media":944,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"__cvm_playback_settings":[],"__cvm_video_id":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[188],"tags":[80,190,189],"class_list":["post-1202","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pharmakologie","tag-ketamin","tag-r-enantiomer","tag-s-enantiomer"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/news-papers.eu\/wp-content\/uploads\/2016\/03\/Ketamin.jpg?fit=1632%2C1224","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p7fR2g-jo","jetpack-related-posts":[{"id":2025,"url":"http:\/\/news-papers.eu\/?p=2025","url_meta":{"origin":1202,"position":0},"title":"Ketamin: pharmakologischer Steckbrief","author":"Michael Bernhard","date":"Februar 12, 2017","format":false,"excerpt":"Auf die Open Access Ressource von Dr. David Lyness von www.propofology.com\u00a0haben wir bereits hingewiesen. Jetzt hat der Kollege eine pharmakologische Kurzcharakteristika von Ketamin publiziert: hier. Beachten Sie den Unterschied zwischen Ketamin als Razemat und dem reinen Enantiomer S-Ketamin (Beispiel: hier). 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Balzer N et al. Low-dose Ketamine For Acute Pain Control\u00a0in the Emergency Department: A Systematic\u00a0Review and Meta-analysis. 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